Abstract
Cyclic analogues of neurotensin (NT) C-terminal fragments NT(8-13) and NT(9-13) were produced via intramolecular nucleophilic substitution of the Tyr(11) phenoxide anion on a 6-bromohexanoyl side chain substituted at position 8 or 9 and tested for NT receptor binding affinity.
MeSH terms
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Amino Acid Sequence
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Humans
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Neurotensin / analogs & derivatives
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Neurotensin / chemical synthesis*
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Neurotensin / metabolism
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Peptide Fragments / chemical synthesis*
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Peptide Fragments / metabolism
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Protein Binding
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Receptors, Neurotensin / metabolism*
Substances
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Peptide Fragments
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Receptors, Neurotensin
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Neurotensin